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One study showed that taking around 100 grams of carbs with 5 grams of creatine increased total muscle creatine by 60 percent.[5] Another showed similar results by taking 5 grams with around 50 grams of carbs, and 50 grams of proteinthe equivalent of two scoops of protein and two bananas, a cup of grape juice, or a cup of cooked rice

The aim is to reduce progression and to reduce the need for future knee replacement or other knee surgeries

Sources: Effects of GLP-1 on appetite and weight | PMC Preserving Healthy Muscle during Weight Loss | PubMed International Society of Sports Nutrition Position Stand: protein and exercise | PubMed Branched-chain amino acids and muscle protein synthesis in humans: myth or reality

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The net result of this activation process is the consumption of 2 molar equivalents of ATP