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These results suggested that AP probe-net induced the accumulation of DNA damage and DNA strand breaks in both THJ-16T and CAL-62 cells (Fig

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Its evidence is preclinical, centred on metabolic and adipose models

The GSH to glutathione disulfide ( GSSG ) ratio is a key indicator of cellular oxidative stress, highlighting the importance of maintaining balanced levels

Treatment with febuxostat did not reduce significantly the progression renal disease, with a fall in eGFR in the placebo group of (-0.47 4.48 ml/min/1.73 m2) vs 0.23 5.26 ml/min/1.73 m2 in the febuxostat group