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In another study involving more than 96,000 patients initiating GLP-1s, 46% of patients with and 65% without Type 2 diabetes discontinued the drugs within one year

Exercise, both resistance and endurance exercise, could be a very important additional therapy for people taking GLP-1 based medications, because exercise decreases, or prevents, the loss of muscle during weight loss, increases muscle strength, and improves performance of daily tasks, Klein says