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Also, high treatment costs, supply constraints, and increasing competition from new obesity and diabetes therapies hinder the market

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Comparative effectiveness of SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas on risk of kidney outcomes: emulation of a target trial using health care databases

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Estimands and robustness assessment Two estimands were used to assess the robustness of the results: Hypothetical strategy: Included data from all randomized participants until initiation or change in symptomatic therapy Treatment policy strategy: Included all data regardless of changes in symptomatic therapy