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The reasons for an increased circulating Hcy are variable and range from imbalanced diet, poor in leafy greens (shortage of folates) or, opposite, entirely vegetarian (shortage of B12), to a bad fit between the diet and the inherited genetic variants of the concerned metabolic enzymes, in many cases circulating in double digit prevalence, which may generate an increased demand (relative shortage) of several dietary substrates [14]

Beyond its role as a free radical scavenger, glutathione is the linchpin of the body's detoxification system

It is produced in the cytosol and then pumped into the mitochondria

Eur J Neurosci 12 : 37213728

Adults across a wide age range use B12 support for different reasons