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9 Holst JJ et.al

--- #Pharmacology #NSAIDs #Diclofenac #Aceclofenac #MedicalEducation #Pharmacy To view or add a comment, sign in Diclofenac vs Aceclofenac Complete Clinical Comparison Class: Both are NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) --- Mechanism of Action: Diclofenac: Non-selective COX-1 & COX-2 inhibitor (more potent, higher GI risk) Aceclofenac: Preferential COX-2 inhibitor (better tolerated, less gastric irritation) --- Adult Dose: Diclofenac Oral: 50 mg 23 times daily Max Dose: 150 mg/day Injection (IM/IV): 75 mg once or twice daily Aceclofenac Oral: 100 mg twice daily Max Dose: 200 mg/day --- Pediatric Dose: Diclofenac 13 mg/kg/day in divided doses Common: 1 mg/kg/dose 23 times daily Aceclofenac Not routinely recommended in children (limited safety data) --- Dose per kg: Diclofenac: 1 mg/kg per dose (max as per adult limits) Aceclofenac: No standard per kg dose (avoid in pediatrics) --- Pregnancy Use: Both drugs Contraindicated in 3rd trimester (risk of premature ductus arteriosus closure) Use in 1st & 2nd trimester only if clearly needed Prefer safer alternatives like Paracetamol --- Effects: Diclofenac Strong analgesic & anti-inflammatory Fast acting Higher GI irritation & ulcer risk Aceclofenac Moderate analgesic effect Better GI tolerance Preferred for chronic conditions --- Side Effects: Common (Both): Nausea, vomiting Gastric irritation Headache, dizziness Serious: GI bleeding (more in Diclofenac) Renal toxicity Cardiovascular risk (long-term use) --- Contraindications: Peptic ulcer disease Severe renal/hepatic impairment NSAID allergy Late pregnancy --- Available Dosage Forms: Diclofenac: Tablets (25, 50 mg) Injection (75 mg/ml) Gel / topical Suppository Aceclofenac: Tablets (100 mg) Combination tablets (with paracetamol, serratiopeptidase) --- Clinical Insight: Diclofenac is more potent but has higher side effect risk

Martinez CS, Peanha FM, Brum DS et al

This is why a single week is rarely a reliable timeframe for assessing progress

Start your intake How Semaglutide Works in Your Body Throughout the Day Semaglutide reaches peak concentration in your bloodstream approximately 1 to 3 days after a weekly injection, with active levels remaining present for up to 7 days