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Funding This work was supported by the National Major Scientific and Technological Special Project for Significant New Drugs Development during the Thirteenth Five-year Plan Period (Grant number: 2020ZX09201-003), National Natural Science Foundation of China (Grant number: 32000985), Key Disciplines Construction Program of Traditional Chinese Medicine (Integrated Traditional Chinese and Western Medicine) during the Thirteenth Five-year Plan Period of Zhejiang province (Grant number: 2017-XK-A35), Zhejiang Provincial Natural Science Foundation (Grant number: LQ21H300003), Zhejiang Province Medical and Health Science Research Project (Grant number: 2021KY666), and Zhejiang Pharmaceutical Association (Grant number: 2019ZYY12)