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No significant adverse events have been reported in trials using doses up to 15 grams per day

Benjamin Natelson, to apply (successfully) for three successive seed grants from the CFIDS Association of America (now Solve ME/CFS Initiative) to investigate, using brain MRI/MRS, whether mitochondrial dysfunction was responsible for the elevations of ventricular lactate that wed observed in ME/CFS [Mathew et al 2009, Murrough et al 2010, Shungu et al 2012]

bioRxiv: May 29, 2020 (Epub ahead of print) [DOI] [Google Scholar] 112.Zhou Y, Zhang L, Song S, Xu L, Yan Y, Wu H, Tong X, Yan H

The evaluation often incorporates indirect markers such as improved fertilization rates, successful embryo development, and clinical pregnancy rates as proxies for oocyte quality

These are complementary mechanisms, though combination effects have not been studied