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While IGF-I remains the biomarker that best reflects endogenous GH secretion, when there is a discordancy with GH and IGF-I levels, it is important for the clinician to be mindful of the associated changes in intra-portal insulin delivery to the liver when interpreting these results in the context of health and when deciding treatment regimens in disease states

J Pharmacol Exp Ther 1995;272:41722.ArticlePubMed 28

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This acupoint stimulation also elevates melatonin levels in the pineal gland, suprachiasmatic nucleus, and ventrolateral preoptic nucleus, leading to increased mRNA expression of melatonin receptors MT1 and MT2