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doi: 10.1016/j.redox.2019.101107 14 GaoLHuaWTianLZhouXWangDYangYet al

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Inhaled salmeterol: maximum 200 micrograms over 24 hours in divided doses not to exceed 100 micrograms over 8 hours starting from any dose Inhaled vilanterol: maximum 25 micrograms over 24 hours NOTE The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is not consistent with therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of a therapeutic dose (by inhalation) up to the maximum dose indicated above

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In fact, the k cat / K m of SQOR toward H 2 S was estimated to be of the order of 10 7 M -1 s -1 ( 7 -fold higher than the rate constant for sulfide addition to disulfide in solution at pH 7.4 and 25 C (0.6 M -1 s -1 ) ( In the proposed catalytic cycle, sulfide first attacks the trisulfide bridge of the enzyme, generating persulfides at both Cys201 and Cys379