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Research has found that after high glucose and high fat culture in vitro , the expression of Pdx1 in primary pancreatic islets decreases, intervention with liraglutide can significantly increase the secretion of Pdx1, while GLP-1R inhibitors can counteract this effect (Cataldo et al., 2021)

Longitudinal analysis of changes in weight and waist circumference in relation to incident vasomotor symptoms: the study of women's health across the nation (SWAN)