[6] Absolute contraindications include hypercalcaemia, hypervitaminosis D, idiopathic infantile hypercalcaemia, or documented hypersensitivity to vitamin D or components of the oil vehicle because additional vitamin D would worsen calcium overload or provoke severe allergic reactions
Additionally, thiazolidinedione (TZD) drugs selectively inhibit ACSL4 activity, significantly reducing lipid peroxidation and ferroptosis (Doll et al., 2017)
However, the process of making ATP also produces reactive oxygen species (ROS), such as hydrogen peroxide, which can damage the cell at higher levels
[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Da Costa L, O'Donohue MF, van Dooijeweert B, Albrecht K, Unal S, Ramenghi U, Leblanc T, Dianzani I, Tamary H, Bartels M, et al
Gianturco S, Ramprasad M, Lin A, Song R, Bradley W