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Final Verdict: Research Comparison Feature Tirzepatide Retatrutide Receptor Targets GLP-1, GIP GLP-1, GIP, Glucagon Half-Life ~5 Days ~6 Days Max Published Weight Loss ~21% (72w) ~24% (48w) Liver Fat Reduction Moderate/High Extreme Primary Research Focus Glycemic Control Metabolic Reset / REE Future Outlook: Post-2025 Research Landscape As we look toward 2026 and beyond, the data from the Phase 3 TRIUMPH trials will likely solidify retatrutides position in the metabolic research hierarchy