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Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21

Changes in the physiological balance between proinflammatory and anti-inflammatory adipokines, as well as changes in the physiological balance of adipokines and proinflammatory cytokines secreted by adipose tissue, may increase the risk of obesity-related asthma by reducing the natural development of immune tolerance [12,13]