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Many show potential, but L-arginine has some of the strongest research behind it

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10 Although there is more limited information about the use of supplements to treat neuropathic pain compared to first-line agents, alpha-lipoic acid (ALA), also known as thioctic acid, and acetyl-L-carnitine (ALC) have shown to be efficacious forms of treatment for diabetic neuropathy with less adverse side effects when compared to the traditional first-line treatment options