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First, BCKAsthe immediate transamination products of BCAAsaccumulate when BCKDH flux is impaired and directly inhibit insulin-stimulated Akt phosphorylation, thereby impairing glucose uptake and mitochondrial oxygen consumption through mTORC1-independent routes ( Figures 2 , 3

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A., Lubbers, L

We highlight mechanisms governing nutrient sensing and peptide secretion by enteroendocrine cells, including novel taste-like pathways