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Freeze-thaw sensitivity is lower than for a peptide, since there is no secondary structure to lose, but aliquoting still avoids repeated stopper punctures and concentration drift from evaporation

Such as intramuscular injections, transdermal creams, drops, sublingual tablets, or capsules

As with any active cosmetic product, introduce it gradually

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Pycnogenol has been shown to have four main effects being its antioxidative effects (914), its anti-inflammatory action (1518), its positive impact on blood circulation (9, 1924) and its reinforcing effects on the extracellular matrix (25, 26) (Figure 1)