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Inhibition of PHGDH effectively reduces glycine availability and has been shown to alleviate fibrosis in experimental models [18]

The conversion from homocysteine to cystathionine by cystathionine -synthase (CBS) is described to be a key player in restoring intracellular cysteine pool as decreasing its expression increases sensitivity to ferroptosis in ovarian cancer cells upon erastin treatment ( However, other systems downstream of cystine uptake can also play an important role

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Therefore, it may only be used off-label when prescribed by an authorized healthcare provider