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With its localization to the SR, nNOS regulates the S-nitrosylation of the calcium release channels, the type 2 ryanodine receptors (RYR2) resulting in release of stored calcium, The localization of nNOS in the plasma membrane allows for direct S-nitrosylation of L-type Ca 2+ channels resulting in increased influx of calcium

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doi: 10.1074/jbc.M116.730564 74 YinW.XuS.WangZ.LiuH.PengL.FangQ.et al

Interestingly, we observed several H3 CDR cysteine-containing peptides that contained various modifications