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Neither peptide therapy nor traditional TRT provides overnight transformation, but both can deliver significant improvements when properly implemented

For people with type 2 diabetes, it's worth noting that rapid improvement in glycaemic control with GLP-1 receptor agonists like semaglutide has been associated with worsening of diabetic retinopathy in some cases, requiring appropriate monitoring

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For those beginning either drug, monitoring food intake, body weight, and activity levels can indicate whats working or needs adjustment

2025 saw a bidding war between Pfizer and Novo Nordisk for Metsera and its portfolio of obesity agents, which was ultimately won by Pfizer for up to $10 billion