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Veggie Wraps: Many fast food places offer wraps loaded with vegetables, which can be lighter than burgers

The lawsuits argue that Novo Nordisk did not meet this obligation

Ben Lynch to discuss epigenetics and what we can do to understand and impact how our genes are expressed

NewsHealth Weight loss drug GLP-1 may have potential to treat depression, improve motivation, study suggests The blockbuster GLP-1 drugs taken by many Americans for diabetes and to aid in weight loss may also have potential for treating major depression, a new study finds

GLP-1 Key Research Facts Full name: Glucagon-Like Peptide-1 incretin hormone of the proglucagon family Primary bioactive form: GLP-1(736)amide 30 amino acids, C-terminally amidated Gene source: Proglucagon gene processed by PCSK1 in intestinal L-cells and brainstem NTS neurons In vivo half-life: Approximately 12 minutes rapidly inactivated by DPP-4 (cleaves His7-Ala8 dipeptide) Primary receptor: GLP-1R (GLP-1 receptor) class B G protein-coupled receptor (GPCR) Signalling: GLP-1R activation cAMP elevation PKA/CREB activation glucose-dependent insulin secretion Additional signalling: PI3K/Akt pathway -cell survival, proliferation, and glucose sensitivity Secretion pattern: Biphasic post-meal release from intestinal L-cells early neural/endocrine peak + late direct nutrient-contact peak Fasting plasma level: ~510 pmol/L