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Long-term administration of prophylactic B12 injections is likely to elevate B12 levels, therefore harm management strategies could include - - regular monitoring of B12 levels, preferably 3-6 monthly

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Liposomal encapsulation in nutraceuticals reduces side effects since effective absorption results in less stress to the gut [18]

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"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity