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Often resolves with dose reduction

The revised D-A-CH-reference values for the intake of vitamin B 12 : Prevention of deficiency and beyond

49 As a core circadian regulator, melatonin stabilizes clock genes (e.g., CLOCK protein), reduces cortisol-mediated immunosuppression, and coordinates rhythmic immune cell activities (e.g., diurnal fluctuations in macrophage phagocytosis), systemically delaying immunosenescence

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