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Name: do semaglutide and tirzepatide work the same vs. Semaglutide: What You Should Know does semaglutide work as good
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Weight gain is not a side effect people report often

Notably, mutations in the GLUT2 gene affect the glucose-lowering efficacy of metformin (Zhou et al., 2016), which may be one of the reasons for individual differences in metformin efficacy