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It is feasible to either lessen the usage of or replace MC in process chemistry, as this review article shows various alternatives to substitute MC by other solvents and solvent mixtures in commercial synthetic processes and column chromatography

Figure 13.6

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Their ability to inhibit A and tau aggregation, enhance A clearance, suppress chronic neuroinflammation, restore mitochondrial and metabolic function, reduce oxidative stress, and promote neurogenesis and synaptic plasticity underscores their significant potential

KPV retains anti-inflammatory activity without melanogenic effects, making it more specific for inflammation research