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Metabolism 65(8):10621079 Moreira GV, Azevedo FF, Ribeiro LM, Santos A, Guadagnini D, Gama P, Liberti EA, Saad M, Carvalho C (2018) Liraglutide modulates gut microbiota and reduces NAFLD in obese mice

For those who have a true deficiency, increasing B12 with supplements can help with weight loss as energy levels will rise, promoting an increase in physical activity (per Healthline )

Furthermore, reconstitution of wildtype (100) or LDL receptor deficient mice( Ldlr -/- ) (101) with Apoe -/- bone marrow accelerates atherosclerotic lesion development without affecting plasma cholesterol levels, demonstrating an atheroprotective role for macrophage apoE

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Alternatively, ethyl bromoacetoacetate can be used as the starting material