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The and sub units of hemoglobin possess high affinity binding sites for lipopolysaccharides (LPS), and leads to macrophage cytokine production and enhances the macrophage binding to LPS

This mechanism initiates the intrinsic apoptosis pathway specifically in senescent cells, while healthy cells maintain different p53 regulation mechanisms and remain unaffected by the peptide administration

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12.2.2 Potential antagonistic effects Conversely, curcumin has been shown to interfere with the action of other chemotherapeutic drugs (e.g., cyclophosphamide, doxorubicin) by activating certain detoxification pathways (like ABC transporters) that pump the drugs out of cancer cells, thereby reducing their effectiveness (244)

Polypodium can also be used topically in a sunscreen