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10.1016/j.cmet.2018.03.001 86

In ex vivo studies using isolated blood vessels, BPC-157 induces vasodilation through increased nitric oxide production, with effects blocked by endothelium removal or eNOS inhibition

This study also included an open-label comparator arm where participants took liraglutide 1.8 mg

Dysbiosis leads to impaired lipid metabolism, resulting in dyslipidemia, a common complication among patients with kidney disease that precipitates atherosclerosis and cardiovascular disorders [93]

Niacinamide pairs with this to boost skin barrier function and even out tone , while Alpha-Arbutin and Bisabolol round out the formula by targeting dark spots and hyperpigmentation for a clearer complexion