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Safety risks in the GLP-1 market: an update on weight loss medication, May 2026 Drug shortages and coverage gaps have led to criminal counterfeiters exploiting Americans demand for blockbuster diabetes and weight loss drugs made with semaglutide and tirzepatide

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Before receiving prescriptions, patients acknowledge understanding that compounded semaglutide and tirzepatide tablets are not FDA-approved products, contain the same active ingredients as branded medications but are prepared by compounding pharmacies rather than pharmaceutical manufacturers, lack the extensive clinical trial data specific to the exact compounded formulation, may have greater batch-to-batch variability compared to mass-manufactured drugs despite quality control efforts, and are prescribed based on physician judgment and patient preference rather than FDA indications

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Here are the general guidelines for oral treatment: 1