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doi:10.1126/sciadv.abf1948 Enebo LB, et al

Decision comparison matrix For users who are comparing these peptides to newer options in the class, the retatrutide vs tirzepatide and retatrutide vs semaglutide comparisons provide additional context about where the next generation of incretin therapies is heading

Proposed mechanisms include enhanced long-term potentiation (a cellular correlate of learning), increased brain-derived neurotrophic factor expression, reduced neuroinflammation, and protection against oxidative stress

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