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The Evolutionary Perspective: Why GLP-1s Matter Heres an angle most weight-loss blogs miss: hunger hormones like GLP-1 exist for survival

This hormone tells the body to release sugar stored in the liver when blood sugar is low

The rationale is straightforward: a 120kg individual has significantly more tissue volume for the peptide to distribute through than a 70kg individual, which affects both the effective concentration at receptor sites and the perceived intensity of side effects

The unknown ingredient purity and potential contaminants in unregulated products pose unacceptable risks during lactation

A detailed knowledge of incretin physiology and pathophysiology will be a prerequisite for designing more effective incretin-based drugs for metabolic diseases.