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The analysis also includes tirzepatide (Mounjaro and Zepbound), which is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 agonist (and classified under A10BX or other blood glucose lowering drugs, excl

GLP-1 receptor agonists were initially developed to improve glycemic control in type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, with additional effects on appetite regulation and gastric emptying later recognized as clinically relevant (Meloni et al

A similar reduction in body weight (approximately 2% vs

We did not try to quantify these successive negative inotropic effects of receptor antagonists as one antagonist may have altered the effect of another

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