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Results: Effect size for desire: 0.49 to 0.61 Effect size for distress reduction: 0.60 to 0.62 25% of treated patients versus 17% placebo achieved clinically meaningful desire increase 35% versus 31% achieved clinically meaningful distress reduction A 52-week open-label extension confirmed sustained efficacy and safety (PMC6819021, PMC6819023)

Pathophysiological synergy: complementarity of surgery and pharmacotherapy The first stage of the TPMO framework, metabolic neoadjuvancy, prioritizes preoperative optimization to enhance surgical safety and ease

The ratio of the Rac1 amount after the trypsin treatment to that without trypsin treatment was calculated by analyzing the western blotting bands using Image J