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The holo TC test only measures B12 that is attached to transcobalamin II, thus giving a much better indication of the available supply

A high B12 can mark an undiagnosed cancer rather than cause one, and the likely direction is the illness raising B12

This is the first large study the authors could find that puts the question to a systematic test, using health records from Penn Medicine, an academic system covering more than 6.5 million patients around Philadelphia, Delaware, and southern New Jersey

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