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Pancreatitis appeared in early animal studies, triggering concerns about long-term pancreatic safety

28 Oral administration does not appear to diminish the glucose-lowering or weight-lowering efficacy of semaglutide, 29 with oral semaglutide comparing favorably when studied against the SGLT-2 inhibitor empagliflozin

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Those off-label prescriptions will eat into monopoly market share for Wegovy and Rybelsus, even if those latter two drugs are still technically covered by patent protection for several more years

It represents a dynamic equilibrium where the amount administered equals the amount eliminated, optimising blood glucose control and appetite regulation whilst minimising adverse effects