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Secondary outcomes were: the K-MMSE, Korean-Color Word Stroop Test (K-CWST), Controlled Oral Word Association Test (COWAT), Korean-Trail Making Test-Elderly's Version (K-TMT-E), Korean Instrumental Activity of Daily Living (K-IADL), Geriatric Depression Scale (GDS), Clinical Dementia Rating Scale (CDR), Clinical Dementia Rating Scale Sum of Boxes (CDR-SB), and measured at baseline, 12 weeks, and 28 weeks (or endpoint)

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The onset of clinical benefit in this secondary analysis therefore precedes substantial weight loss and predates the achievement of target maintenance dosing, although the time-to-benefit estimates carry wider confidence intervals than the primary endpoint