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Mechanistically, ferroptosis is driven by the accumulation of lethal phospholipid hydroperoxides (PL-OOH), primarily derived from polyunsaturated fatty acid (PUFA)-containing phospholipids

The PPI network diagram emphasizes high scores for several glutamate metabotropic receptors (GRMs) such as GRM2, GRM5, GRM3, GRM8, GRM1, and GRM4, alongside other relevant proteins such as GRIA2, SLC1A2, GRIK5, and GRIN1

GHK-Cu, or glycyl-L-histidyl-L-lysine copper, occurs naturally in human plasma but declines with age

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Aspergillus cristatus attenuates DSS-induced intestinal barrier damage through reducing the oxidative stress, regulating short-chain fatty acid and inhibiting MAPK signaling pathways