Native GLP-1 functions as a rapid-response, meal-related hormone with a half-life measured in minutes, while semaglutide is an engineered therapeutic agent with a half-life measured in days
In the ELIXA and the EXSCEL trials, GLP-1RAs (once daily lixisenatide and once weekly exenatide, respectively) didnt provide benefit in MACE reduction compared to placebo, but were non-inferior to placebo for the primary composite outcome of MACE
[DOI] [PubMed] [Google Scholar] 37.Halvorsen B.L., Carlsen M.H., Phillips K.M., Bhn S.K., Holte K., Jacobs D.R., Jr., Blomhoff R
Genetic testing is used to see if a person has the genetic variants that cause pEDS
It isn't clear how long these side effects last, they'll likely disappear when the medication is stopped, but any damage to the teeth is permanent