Of course, this approach is quite demanding for the patient, who is required to undergo a, even if simple, surgical procedure, but the sensor lifetime makes this system a good and appealing alternative
Subcutaneous tissue is densely populated with mast cells, and cationic peptides are established activators of the MRGPRX2 receptor on human skin mast cells, triggering degranulation and histamine release through a signalling cascade that has been characterised in some detail in primary human skin mast cells
GonzlezEnseat International Journal of Dermatology 58(12):p 1466-1467, December 2019
Die optimale Wirkung entwickelt sich meist nach 1-2 Wochen regelmiger Anwendung, da sich die krpereigenen Rhythmen an die DSIP-Supplementierung anpassen mssen
Supported once-weekly dosing based on pharmacokinetic findings