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[DOI] [PMC free article] [PubMed] [Google Scholar] 176.Bennuri S.C., Rose S., Frye R.E

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Healthy beta cells secrete a burst of insulin into the portal circulation at the onset of glucose intake, with approximately 70% of the insulin cleared by the liver and not entering the systemic circulation, whereas subcutaneous insulin enters the systemic circulation with some delay and is removed relatively slowly