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The analysis focused on three classes of antidiabetic medications: GLP-1RAs, DPP-4is, and SGLT-2is

Journal of the European Academy of Dermatology and Venereology

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Excessive iron loading increases the expression of M1-associated inflammatory mediators, including IL-6, TNF-, and IL-1, while suppressing M2 markers such as transglutaminase 2 (TGM2), so efficiently guiding polarization toward the pro-inflammatory M1 phenotype (97)