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Mohammad et al., 2018) reviewed in (Hubbard and Schedl, 2019)) (Figure 2)

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 99% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Passive transfer of sera or purified IgG antibodies from mice and baboons vaccinated with Sm-p80 DNA into nave mice with subsequent cercarial challenge resulted in decreases in adult worms, hepatic eggs and egg hatching from tissues, suggesting that antibodies play a significant role in Sm-p80-mediated protection (135)