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The headline results at 80 weeks were: 12 mg dose: average weight loss of 28.3% (approximately 70.3 lbs / 31.9 kg) 9 mg dose: average weight loss of 25.9% (approximately 64.4 lbs / 29.2 kg) 4 mg dose: average weight loss of 19.0% (approximately 47.2 lbs / 21.4 kg) Placebo: average weight loss of just 2.2% Perhaps most striking was the proportion of patients hitting bariatric-surgery-level outcomes: at the highest dose, 45.3% of participants lost 30% or more of their body weight , and 65.3% reduced their BMI to below 30 kg/m meaning they were no longer classified as living with obesity by the end of the trial

in StatPearls (2024)

Weight Loss Pens: GLP-1 and GIP pen protocols are medically guided and reviewed by registered UK healthcare practitioners under corresponding regulatory mandates.

7.8 Avoid Extreme Restriction Very low-calorie diets ( 1520%) Significant caloric restriction Lean mass loss Persistent gastrointestinal symptoms May increase vulnerability

Done properly, this routine poses little risk, but everything from improper techniques to poorly washed hands increases the risk of injury or infection