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The scales used were the Mini-Mental State Examination (MMSE) and the Wechsler Memory ScaleFourth Edition (WMS-IV)

What they found (this is the exciting part) 32% fewer postoperative complications Hospital stay shorter by 1.6 days 28% reduction in opioid requirement Lower pain scores Better recovery quality & satisfaction Patients with: CYP2D6 poor metabolizer status higher IL-6 & TNF- OPRM1 A118G higher cortisol & worse pain control Most importantly: Using genetics to guide therapy reduced complication risk by ~45%

They are common in childhood and harmless

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