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This is consistent with the previous findings that hypoxia-response genes were upregulated in the islets of diabetic, but not prediabetic, db/db mice in an inverse relationship with unfolded protein response gene expression 28,33

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1 H NMR (500 MHz, CDCl 3 ) 7.887.67 (m, 16H, NH and ArH 15), 7.61 (s, 1H, N H H), 5.88 (s, 1H, NH H ), 3.623.53 (m, 2H, H 2 -7), 3.46 (s, 2H), 3.40 (s, 2H), 3.24 (dd, J = 12.0, 6.0 Hz, 2H, H 2 -3), 1.811.61 (m, 6H, H 2 -4, H 2 -5 and H 2 -6)

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