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Oral Small-Molecule GLP-1 Receptor Agonists: Mechanistic Insights and Emerging Therapeutic Strategies

In the cyclosporine A induced nephrotoxicity model of the human proximal tubular epithelial cell line, schisandrin B could reduce the cytotoxicity caused by oxidative stress during the application of immunosuppressants by reducing the release level of intracellular ROS and lactate dehydrogenase and increasing the level of mitochondrial membrane potential and glutathione (GSH) (61)