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This review focuses on recent studies, demonstrating the actions of local IGF-I/IGF-IR signaling in (a) supporting skeletal development and remodeling, (b) cross-talk with other autocrine/paracrine pathways in the bone, (c) mediating cell-cell interactions between various types of skeletal cells, and (d) integration with systemic signals to produce skeletal anabolism

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Proline, with its rigid cyclic structure, disrupts the amyloid arrangement , Pramlintide does not aggregate and is therapeutically usable

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However, the metabolic mechanisms involved in hair regeneration still require further exploration