retatrutide type 2 diabetes phase 2 results 2024 ada Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, 3 Phase III retatrutide study demonstrates

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CrossRef Liver-specific inactivation of Cideb improves metabolic profiles and ameliorates steatohepatitis and fibrosis in animal models for MASH Jianhua Zhang, Xujie Liu, Xian Jin, Xudong Mao, Xueli Xu, Xing Zhang, Ke Shang, Yuan Xu, Yanhuan Zhang, Guofeng Meng, Ming Yue, Guoqing Cai, Song Yang, Jinyu Huang, Jianwu Fang, Ling Pan, Lei Jiang, Stella Shi, Jianyong Shou Pharmacological Research .2025

If "exercise mimetic" is the research framing, SLU-PP-332 is the class-defining compound

Phase 3 TRIUMPH results are expected in 2026 and 2027, and Health Canada approval is likely in 2027 or 2028 if the late data holds up

For more context on laxative-style options, you can also review whether you can take a laxative with Ozempic