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The practical meaning of this 4-year difference is that biologics retain full commercial pricing power during the period roughly years 9 through 13 post-approval when a drug is typically at or near peak revenue

doi:10.1016/j.drudis.2016.01.013 198

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In these cases, provider evaluation must address whether baseline thyroid function is stable, TSH is well-controlled, and whether introducing a GLP-1 agent poses any incremental autoimmune risk for that individual