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Together, these observations suggest that receptor-level signaling and anti-inflammatory effects alone may be insufficient to produce functional improvement in energy-demanding tissues such as skeletal muscle and brain, where substrate turnover and mitochondrial metabolic throughput are critical determinants of tissue function

Instead, they use testosterone esters molecules like testosterone cypionate that modify how the hormone is absorbed and metabolized

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This assertion is backed by some early animal research

10.2337/db23-0553 40 KahlesF.MeyerC.MollmannJ.DieboldS.FindeisenH